By Dimiter S. Dimitrov, James D. Marks (auth.), Antony S. Dimitrov (eds.)
With sales from the pinnacle 5 healing antibodies accounting for a majority of the new pharmaceutical revenues, the learn and improvement within the box has exploded over the last numerous years and is predicted to develop with new rising monoclonal antibodies like Numax, Lucentis, Actemra, and others. In Therapeutic Antibodies: tools and Protocols, top specialists from educational laboratories and biotechnology businesses current an intensive set of protocols for the invention and improvement of healing antibodies, that includes sections dedicated to recombinant antigens, antibody libraries, antibody discovery, antibody engineering, and antibody preclinical improvement. Written within the hugely winning Methods in Molecular Biology™ sequence layout, the chapters comprise short introductions to their respective topics, lists of the required fabrics and reagents, step by step, conveniently reproducible laboratory protocols, and notes highlighting tips about troubleshooting and warding off recognized pitfalls.
Comprehensive and state-of-the-art, Therapeutic Antibodies: equipment and Protocols serves as a key source for researchers and antibody engineers investigating and taking part during this speedily becoming healing marketplace segment.
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Biol. 382, 779–789. Chapter 2 Preparation of Recombinant Viral Glycoproteins for Novel and Therapeutic Antibody Discovery Yee-Peng Chan, Lianying Yan, Yan-Ru Feng, and Christopher C. Broder Abstract Neutralizing antibodies are a critical component in the protection or recovery from viral infections. In the absence of available vaccines or antiviral drugs for many important human viral pathogens, the identification and characterization of new human monoclonal antibodies (hmAbs) that are able to neutralize viruses offers the possibility for effective pre- and/or post-exposure therapeutic modalities.