By John C. Krantz Jr. (auth.), Philip Needleman Ph. D. (eds.)
Nitroglycerin and different natural nitrates were used for over a century within the remedy of angina pectoris. thousands of sufferers, in the course of the global, have positioned nitroglycerin capsules below the tongue and feature skilled speedy and dramatic aid from the chest soreness that regularly happens as a manifestation of affliction of the coronary arteries. The empirical remark of the secure use of nitrates for tile relief of the indicators of angina have resulted in their common clinical reputation. using natural nitrates preceded any wisdom in their mechanism of motion or their final metabolic destiny. therefore, extra easily acknowledged, even supposing sub lingual nitrates helped the sufferers, little used to be identified pertaining to what those medicines do to the physique or what the physique does to the medication. a considerable variety of investigators have desirous about those questions specifically over the past twenty years. now we have significantly extra perception into the pathways of decay of natural nitrates and the connection of the metabolic tactics to the organic motion of those brokers. equally, significant attempt has been expended in knowing the mechanism of motion of those brokers without delay on vascular delicate muscle and on cardiac paintings and function. ultimately, there's a extra substantial figuring out of the body structure of the coronary stream in addition to the" pathophysiologic manifestations of myocardial disease.
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N' ::s ()Q 34 MARC G. BOGAERT chromatograms of plasma extracts from a human volunteer are shown, before and after oral administration of 5 mg isosorbide dinitrate. In another study, the possibility of separating with GLC a mixture of the di- and mononitrates of isosorbide, isomannide and isoidide, was demonstrated (ROSSEEL and BOGAERT, 1973 a). IV. Use of Labeled Products For the different series of nitrates, labeled compounds have been used. , 1971). , by CREW and DICARLO (1968); DICARLO et ai.
Agr. Chern. 47, 918-991 (1964). : Open-chain nitrogen compounds, Vol. 2, pp. 483--490. A. Benjamin 1966. : Chemistry and technology of explosives. New York: MacMillan Co. 1965. CHAPTER 3 Organic Nitrates: Analytical Techniques MARC G. BOGAERT With 1 Figure Most analytical techniques in the field of organic nitrates have been developed for the study of explosives or for pharmaceutical purposes; therefore, these techniques are often only qualitative or, if quantitative, their limit of detection is far above the concentrations one can expect to occur in biological fluids.
Amer. Oil chern. Soc. 41, 44-46 (1964). ,VAN: The reaction of n-butyl nitrate with alkaline hydrosulfides. J. Amer. chern. Soc. 75, 4259--4263 (1953). : Sidgwick's organic chemistry of nitrogen. 87-94. Oxford: Clarenden Press 1966. , JOHNSON, E. : Mechanism of tolerance development to organic nitrates. 1. Pharm. expo Ther. 184,709-715 (1973). , HAYDEN, A. : Infrared spectra of some compounds of pharmaceutical interest. 1. Ass. Offic. Agr. Chern. 47, 918-991 (1964). : Open-chain nitrogen compounds, Vol.