By Michel Lebel
In the course of our little while on the earth, all of us endure the hugely advanced technique of getting older, and with it, we adventure the various physiological indicators. reports of untimely getting older have produced loads of info that provides a few elements of getting older a greater figuring out. This e-book explores Werner's syndrome. to a couple, Werner's syndrome is taken into account a comic strip of getting older, yet others will locate it attention-grabbing that just one mutated human gene (WRN) can result in a large number of advanced phenotypes which are often linked to getting older.
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Extra info for Molecular mechanisms of Werner's syndrome
Sample text
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc Natl Acad Sci USA 2001; 98:3174-3179. 46. Huang P, Pryde FE, Lester D et al. SGS1 is required for telomere elongation in the absence of telomerase. Curr Biol 2001; 11:125-129. 47. Karow JK, Constantinou A, Li JL et al. The Bloom’s syndrome gene product promotes branch migration of holliday junctions. Proc Natl Acad Sci USA 2000; 97:6504-6508. 48. Sun H, Karow JK, Hickson ID et al. The Bloom’s syndrome helicase unwinds G4 DNA.
27) proteins are authentic homologs of WRN. Most notably, whereas E. coli RecQ, S. cerevisiae Sgs1 and S. pombe Rqh1 are devoid of the exonuclease domain, it is present in X. laevis FFA-1 and mouse Wrn. Five RecQ-like DNA helicases were identified to date in human cells. 31,33 Mutations in three of these genes result in hereditary genomic instability disorders characterized by predisposition to malignancies and/or early senescence. WS, Bloom syndrome (BS) and Rothmund-Thomson syndrome (RTS) arise from autosomal recessive mutations in WRN,8,9 BLM28,34 and RecQL4 ,35,36 respectively, (for review see 37).
Cooper MP, Machwe A, Orren DK et al. Ku complex interacts with and stimulates the Werner protein. Genes Dev 2000; 14:907-912. 29. Oakley TJ, Hickson ID. Defending genome integrity during S-phase: putative roles for RecQ helicases and topoisomerase III. DNA Repair 2002; 19:175-207. 30. Sakamoto S, Nishikawa K, Heo SJ et al. Werner helicase relocates into nuclear foci in response to DNA damaging agents and colocalizes with RPA and Rad51. Genes Cells 2001; 6:421-430. 31. Constantinou A, Tarsounas M, Karow JK et al.