By György Berencsi III
The human foetus is separated from the maternal blood by way of the syncytiotrophoblast prompted by means of endogeneous human retrovirus-encoded proteins. This barrier is a hugely constructed one, which suppors apical-basolateral shipping of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal shipping of epitope- and paratope-bearing entities can impression the developping fetal immune method while pregnant. The bidirectional maternal-fetal move of cells are of much more significance while pregnant. Maternal cells with latent viruses shipping viruses with out impairment of fetal improvement. Cells with premaligant and malignant genetic transformation also are transported to the fetus. Fetal and neonatal tumours are initiated through such cells regardless of the antitumour capability of fetal organism. at the contary, the fetal cells fix maternal tissue injouries and live on within the organisms of the recipients for many years. those own new results for the neonatal immunity and organ transplatation surgery.
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Mol Immunol 44:3389–3397. 014 Csuka D, Molvarec A, Derzsy Z, Varga L, F€ ust G, Rigo´ J Jr, Proha´szka Z (2010) Functional analysis of the mannose-binding lectin complement pathway in normal pregnancy and preeclampsia. J Reprod Immunol 87:90–96. 004 Czeizel AE, Puho´ EH, Acs N, Ba´nhidy F (2008) Delineation of a multiple congenital abnormality syndrome in the offspring of pregnant women affected with high fever-related disorders: a population-based study. Congenit Anom (Kyoto) 48:158–166. x Dawe GS, Tan XW, Xiao ZC (2007) Cell migration from baby to mother.
CD56bright NK cells may represent predecessors to CD16+ mature NK cells and can be seen both in the peripheral blood of pregnant women and enriched at the fetomaternal interface (Moffett-King 2002). HLA-C is the only known polymorphic MHC or MHC-like molecule that is expressed by trophoblast cells and is the dominant ligand for the members of the KIR family of receptors that have two immunoglobulin-like domains (KIR2D). These might be activating (KIR2DS) or inhibitory (KIR2DL) receptors. KIR haplotypes comprise two groups, A and B.
2010). Death of the mother and fetus, abortion, premature delivery, or death of a live-born baby soon after birth are common complications of Hepatitis E virus (HEV) infection during pregnancy (Smith 2001). Rift valley fever virus (RVFV) is causing frequently abortions (Ikegami and Makino 2011). e. acute or chronic chorioamnionitis. Even in the absence of fetal 34 G. Berencsi III and M. Taka´cs viral infection, the inflammatory response originating in the placenta and decidua induced an inflammatory process with potential damage in fetal organs (Cardenas et al.