Carbohydrate Chemistry, Volume 33 by Royal Society of Chemistry

By Royal Society of Chemistry

Carbohydrate Chemistry offers evaluate assurance of all courses proper to the chemistry of monosaccharides and oligosaccharides in a given 12 months. the volume of study during this box showing within the natural chemical literature is expanding as a result of the better value of the topic, particularly in components of medicinal chemistry and biology. In no a part of the sphere is that this extra obvious than within the synthesis of oligosaccharides required by means of scientists operating in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now rather well proven, for instance, by way of the practise of particular carbohydrate- dependent antigens, in particular cancer-specific oligosaccharides and glycoconjugates. insurance of issues reminiscent of nucleosides, amino-sugars, alditols and cyclitols additionally covers a lot examine of relevance to organic and medicinal chemistry. every one quantity of the sequence brings jointly references to all released paintings in given parts of the topic and serves as a finished database for the lively study chemist. expert Periodical experiences offer systematic and designated overview assurance in significant parts of chemical learn. Compiled by means of groups of major experts within the suitable topic components, the sequence creates a distinct provider for the lively study chemist, with average, in-depth bills of growth specifically fields of chemistry. topic assurance inside of assorted volumes of a given name is the same and book is on an annual or biennial foundation.

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A novel method for activating the C-1 hydroxyl group of a sugar for glycoside formation involves the in situ formation of a glycosyl imidate by treatment with an oximoxy-trisdimethylaminophosphonium salt. 9 The method requires development before it be claimed as an efficient new glycosylation process. 12 Mixed glycosyl carbonates, made in good yield from 1-0unprotected sugars and succinimidyl carbonates, decarboxylate on treatment with trimethylsilyl triflate to give glycosides and disaccharides.

G. J. J. Fleet, Tetrahedron: Asymmetry, 1999,10, 355. P. E. Stiitz, Synlett, 1999, 1787. N. N. D. Dhavale, J. Org. ,1999,64,1715. J. Tronchet, S. Zerelli and G. Bernardinelli, J. Carbohydr. , 1999, 18, 343. E. M. Paton, Carbohydr. , 1999,321,24. O. E. M. Paton, Carbohydr. , 1999,322, 1 . S. Jarosz, S. Skora, A. Stefanowicz, M. Mach and J. Frelek, J. Carbohydr. , 1999,18,961. S. Jarosz, M. Mach and S . Skora, Synlett, 1999, 313. A. Marco, M. Carda, E. Falomir, C. Palomo, M. A. Ortiz and A. , 1999,40, 1065.

1999, 22, 237 (Chem. , 1999, 131, 199 896). S. A. Begum, Carbohydr. , 1999,315,70. J. D. J. J. J. Griffin, Tetrahedron, 1999,55,2857. 1 Synthesis of Monosaccharides Glycosides. 2 In more specific work Dondoni and Marra have reviewed the use of ‘thiazolylketoses’ in the preparation of ketosides. 1 Methods of synthesis of glycosides. - Solid, essentially neutral and environmentally benign catalysts are being used increasingly for catalysing glycoside formation from free sugars. 6 Montmorillonite K- 10 catalysed the condensation of 3,4-di-O-protected olivose (2,6-dideoxy-~arabino-hexose) with (hydroxymethy1)cyclohexane with 96% efficiency, and a 6-unsubstituted glucoside to give 1,6-linked disaccharide derivatives with 77% efficiency.

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