By Jean C. Shih, Qin-Shi Zhu, Joseph Grimsby, Kevin Chen, Jack Shih (auth.), P. M. Vanhoutte, P. R. Saxena, R. Paoletti, N. Brunello, A. S. Jackson (eds.)
This quantity includes the complaints of the invited lectures of the second one overseas Sym posium on SEROTONIN from telephone Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The assembly was once held below the co-sponsorship of the Serotonin membership, the Giovanni Lorenzini scientific beginning, and the Fondazione Giovanni Lorenzini. This quantity discusses the foremost exploration in wisdom that has happened lately of the complicated position that five- hydroxytryptamine (serotonin) performs in future health and illness. In par ticular, those court cases spotlight significant breakthroughs in molecular biology and type of receptor subtypes which are liable for the numerous activities of the monoamine. The ever expanding significance of serotonin in relevant legislation, no matter if autonomic or behavioral is represented via quite a few chapters ready by means of global specialists. also, the function of serotonin in peripheral organs is usually mentioned. for this reason, this quantity offers the reader with a special, updated evaluation of this interesting and novel zone of technological know-how. those lawsuits evidently are of significant curiosity, not just to the researchers without delay engaged within the quest for the knowledge and unraveling of the activities of the interactions with serotonin as a massive neurohumoral mediator, but in addition to all students and clinicians who desire to collect a greater figuring out of the functioning of the mind and of peripheral organs. because this quantity was once developed as a compilation of invited lectures, the clinical content material and the evaluations expressed within the chapters are the only real accountability of the authors.
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Additional info for Serotonin: From Cell Biology to Pharmacology and Therapeutics
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Hoyer, D. N. (1989) 'The pharmacology of the terminal 5-HT autoreceptors in mammalian brain: evidence for species differences', Trends in Pharmacological Sciences 10, 130-132. K. (1992) 'Identification of a single amino acid residue responsible for the binding of a class of 13adrenergic receptor antagonists to 5-Hydroxytryptamine'A receptors', Mol. Pharmacol. 41, 695-698. R (1992) 'Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HTz receptor from a human to a rat pharmacology', FEBS Lett.
MACCHI, L. SCHECHTER, D. URQUHART, J. ZGOMBICK, M. DURKIN, R. WEINSHANK, and T. BRANCHEK Synaptic Pharmaceutical Corporation 215 College Road Paramus, New Jersey 07652 USA ABSTRACT. Five human serotonin receptor subtypes belonging to the 5-HT 1 subfamily (5-HTIA' 5-HTID~' 5-HT IDP [and its species homologue: rat 5-HT IB], 5HT 1E, and 5-HT1F) have now been cloned and characterized. The cloning of these subtypes has settled the controversy over the relationship between the 5-HT IB and 5-HTID receptor sites (termed pharmacological subtypes) by providing the underlying genes (termed genetic subtypes) that encode these receptors.
6). The most recent addition to the family of 5-HT1 receptor clones is the 5-HT lF receptor clone by Adham et al. a. 5-HT6 [24]) receptor clone by Amlail(y et al. [25]. These clones represent species homologue of the same genetic subtype. This intronless clone is coupled to inhibition of adenylate cyclase activity, as are all other members of the 5-HT1 subfamily. 5 [23,25]). The 5-HT 1F receptor is most homologous (amino acid sequence) to the 5-HT lE receptor and is found in the eNS (especially in the hippocampus [25]) and in the periphery, with especially high expression levels found in the uterus and in the mesentery [23].