By Andrea Spanu
This thesis studies on a singular approach for extracellular recordings of the job of excitable cells, which depends on an natural, charge-modulated field-effect transistor (FET) known as OCMFET. The booklet exhibits how, due to the intrinsic biocompatibility, lightness, and inexpensiveness of the cloth used, this new method is ready to triumph over numerous difficulties general of of “classic” digital and bioelectronic. It presents an entire description of the procedure, including a complete document of the profitable experimental trials performed on either cardiac and nerve cells, and a concise but complete evaluation of bioelectronic interfaces and natural sensors for electrophysiological applications.
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Extra info for Organic Transistor Devices for In Vitro Electrophysiological Applications
Sample text
Meyburg, Sven, Goryll, Michael, Moers, Jürgen, Ingebrandt, Sven, Böcker-Meffert, Simone, Lüth, Hans, Offenhäusser, Andreas: N-Channel field-effect transistors with floating gates for extracellular recordings. Biosens. Bioelectron. 21(7), 1037–1044 (2006) 63. : Depletion type floating gate p-channel MOS transistor for recording action potentials generated by cultured neurons. Biosens. Bioelectron. 19(12), 1703–1709 (2004) Chapter 3 Organic Devices for Electrophysiological Applications It is hard to think about something, in the recent past, that affected our lives more than field effect transistors and plastic materials.
For instance, it has been demonstrated that employing a polyelectrolyte gate insulator can suppress parasitic bulk doping of the organic semiconductor and ensures field-effect operation instead of electrochemical doping [15]. The possibility to gate an organic transistor in a liquid environment by exploiting the formation of an EDL (which acts as a capacitor with a very high capacitance), makes the EGOFET a very interesting candidate for biosensing applications. The applicability of EGOFETs for such applications has been demonstrated by Kergoat et al.
Soc. Neurosci. 19(16), 6767– 6773 (1999) 43. : Joining microelectronics and microionics: nerve cells and brain tissue on semiconductor chips. Solid-State Electron. 52(9), 1364–1373 (2008) 44. : Electrical interfacing of nerve cells and semiconductor chips. Chemphyschem: Eur. J. Chem. Phys. Phys. Chem. 3(3), 276–284 (2002) 45. : Neuron-silicon junction with voltage-gated ionic currents. Eur. J. Neurosci. 10(6), 1956–1962 (1998) 46. : Neuron adhesion on a silicon chip probed by an array of field-effect transistors.