By Krzysztof W. Pankiewicz, Barry M. Goldstein
Inosine Monophosphate Dehydrogenase: an important Therpeutic Target presents a comphrensive examine the chemotherapeutic inosine monophosphate deydrogenase. as well as an outline of the sector, this quantity examines the molecular biology and gentics, the constitution and mechanisms of IMPDH, inhibitor layout, medical purposes, and new tendencies for the longer term.
Human IMPDH exists as isoforms, sort I and kind II. kind I is expresses constitutively in common cells, whereas style II is expressed predominantly in melanoma cells and activated lymphocytes. therefore, the sort II is an enormous goal for the improvement of anticancer and immunosuppressive medicines. Inosine Monophosphate Dehydrogenase: an important healing Target offers a complete examine the chemotherapeutic objective inosine monophosphate dehydrogenase. This quantity comprises sections on molecular biology and genetics, constitution and mechanism, and inhibitor layout and scientific functions.
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Because tiazofurin reduced G T P concentration in cells by 50% at 12 hr after admmstration tiazofurin was followed 12 hr later by quercetin. In this sequential administration synergism was observed in both growth inhibition and clonogenic assays. The combination also yielded synergistic reduction of IP concentration in the cells which may explain, at least in part, the synergistic action of tiazofurin and quercetin in O V C A R - 5 cells. These results support the concept that drugs such as tiazofurin and quercetin attacking different biochemical targets in the same pathway and blocking in separate phases of the cell cycle can provide synergistic interaction.
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Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin i n human ovarian carcinoma cells. Life Sci. 1999, 64, 1869-1876. 51. ; Weber, G . Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells. Oncol. Res. 1998, 10, 117-122. 52. ; Weber, G . Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells. Life Sci. 1998, 63, 1975-1981. W. ; ACS Symposium Series;Washington, American Chemical Washington, DC, 2003.