In Vivo Perfusion and Release of Neroactive Substances. by Alejandro Bayon

By Alejandro Bayon

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7 (1981) 5 7 5 . 6. Harper, J . F . , a n d Brooker, G . F e m t o m o l e sensitivity radioimmunoassay for c y c l i c A M P and c y c l i c G M P after 2 ' - 0 - a c e t y l a t i o n by acetic a n h y d r i d e in a q u e o u s solution. J. Nucleotide Cyclic Res. 1 (1975) 2 0 7 - 2 1 8 . 7. Herrling, P. L , a n d H u l l , C . D . lontophoretically applied d o p a m i n e depolarizes a n d hyperpolarizes the m e m b r a n e of cat c a u d a t e neurons. Brain Res. 192 (1980) 4 4 1 - 4 6 1 . 8.

L , K e b a b i a n , J . W . , a n d G r e e n g a r d , P. Characterization of a dopamine-sensitive a d e n y l a t e c y c l a s e in the rat c a u d a t e n u c l e u s . /. Neurochem. 25 (1975) 1 4 3 - 1 4 9 . 4 . G a d d u m , J . H . P u s h - p u l l c a n n u l a e , /. Physiol. (London) 155 (1961) 1 - 2 P . 5 . G o r e l l , J . M . , C a l l a h a n , M . J . , a n d S c h o e n e r , E. P. Regulation of a c e t y l c h o l i n e release in the rat c a u d a t e n u c l e u s . S o c .

Neurobiological Applications In t h e past f e w y e a r s , w e h a v e d i r e c t e d s o m e of o u r efforts t o w a r d t h e investigation of striatal f u n c t i o n . E n d o g e n o u s n e u r o a c t i v e s u b s t a n c e s h a v e b e e n c o l l e c t e d (5, c o r d e d (17, 19) a n d , m o r e r e c e n t l y , c e l l u l a r a c t i v i t y h a s b e e n r e ­ 18) in t h e p e r f u s e d n e o s t r i a t u m . T h e p r i m a r y c o n c e r n of t h e s e studies h a s b e e n t h e r o l e of d o p a m i n e in c y c l i c n u c l e o t i d e production/ release a n d n e u r o n a l d i s c h a r g e .

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