By Henry G. Kunkel and Frank J. Dixon (Eds.)
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Macrophages spread under the influence of alternative pathway activation, and this reaction is regarded as an expression of cell activation. , 1979a). Recently, it was found that Bb imparts the same effect on peripheral monocytes (Sundsmo and Gotze, 1979). , 1979a; 42 HANS J. MULLER-EBERHARD AND ROBERT D. SCHREIBER Sundsmo and Gotze, 1979). , 1979). uiuo by two functionally antagonistic complement reaction products. The influence of complement reaction products on cell behavior and function is an area of research that is still in its infancy.
1978). , 1979). , 1979). , 1979) or to the PROTEINSOF THE Molecular TABLE VIII MEMBRANE ATTACK PATHWAY OF COMPLEMENT Protein weight No. of chains c5 C6 c7 C8 c9 180,000 128,000 121,000 154,000 72,000 2 1 1 3 1 Electrophoretic mobility PI P2 P2 Y1 CY Serum conc. (CLdml) 70 60 55 55 60 31 ALTERNATIVE PATHWAY OF COMPLEMENT "J . 9. Assembly of an intact cytolytic alternative pathway from eleven purified proteins of human serum. Reaction mixtures (each 160 pl) containing 10' erythrocytes, MgGVB, and various amounts of either C4-depleted serum or the isolated component mixture were incubated for 10 minutes at 37°C.
1980). ” If the surface on which the C3b resides lacks “plH-antagonists,” the discriminatory site of C3b remains unengaged, and consequently unrestricted p1H binding occurs. C3bINA rapidly cleaves C3b to which P1H is bound, and the alternative pathway is not activated. On surfaces that possess structures that function as “PlH-antagonists,” binding of P1H to C3b is reduced and C3b is free to bind factor B. These conditions allow formation of the C 3 convertase, amplification via C3b-dependent feedback, generation of the C5 convertase, and activation of the membrane attack pathway.