Vaccines against Allergies by Melanie L. Conrad, Harald Renz, Kurt Blaser (auth.), Rudolf

By Melanie L. Conrad, Harald Renz, Kurt Blaser (auth.), Rudolf Valenta, Robert L. Coffman (eds.)

The pathomechanisms of hypersensitivity are rather good investigated and the disease-causing allergens are characterised in nice aspect all the way down to their molecular constructions. we're hence starting to see numerous new techniques for allergen-specific immunotherapy at the horizon, a number of of that are summarized during this factor. It therefore turns out that hundred years after the 1st experimental makes an attempt to “desensitize” hayfever sufferers we're now able to constructing strong and rational different types of immunotherapy which carry promise for curing hypersensitivity victims and at last may possibly let genuine prophylactic vaccination opposed to allergic reaction. it really is therefore relatively attainable that hypersensitivity could develop into eliminated related as yes different types of infectious illnesses via vaccination.

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J Exp Med 206:2869–2877 Daeron M, Malbec O, Latour S, Arock M, Fridman WH (1995) Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 95:577–585 Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK (2008a) IL-4 inhibits TGF-betainduced Foxp3+T cells and, together with TGF-beta, generates IL-9+IL-10+Foxp3(-) effector T cells. Nat Immunol 9:1347–1355 Dardalhon V, Korn T, Kuchroo VK, Anderson AC (2008b) Role of Th1 and Th17 cells in organspecific autoimmunity.

1999). A similar result emerged from intradermal testing, with 8 of 23 and 13 of 23 of the birch pollen allergic subjects failing to react to 1 lg/ml concentrations of the fragment mixture and the trimer, respectively. Clear dose response effects were seen with each of the allergen derivatives. The Bet v 1 fragments were tested separately and both were shown to be hypoallergenic in nature. A second study produced very similar results (Pauli et al. 2000). However it was observed that there was a very large inter-subject variation in the end-point of the intradermal tests, although both derivatives showed hypoallergenic characteristics to one degree or another.

2003). Steric hindrance of the IgE-binding sites is the probable explanation for the hypoallergenic characteristics. Skin prick tests with concentrations of 100 lg/ml of the fragments or the trimer in subjects with a positive response to native Bet v 1 showed that 18 of 23 and 15 of 23 subjects failed to react to the fragment mixture and the trimer, respectively (van Hage-Hamsten et al. 1999). A similar result emerged from intradermal testing, with 8 of 23 and 13 of 23 of the birch pollen allergic subjects failing to react to 1 lg/ml concentrations of the fragment mixture and the trimer, respectively.

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