By Scott R. Barnum;Bernard J. Morley;Mark J. Walport
The supplement FactsBook comprises entries on all parts of the supplement procedure, together with C1q and Lectins, C3 relatives, Serine Proteases, Serum Regulators of supplement Activation, phone floor Proteins, and Terminal Pathway Proteins. area constitution diagrams are included to obviously illustrate the relationships among the entire supplement proteins, either inside households and among households. The FactsBook additionally comprises the cDNA sequences, marked with intron/exon barriers, to be able to facilitate genetic experiences. Key good points * comprises the cDNA sequences, marked with intron/exon limitations, facilitating genetic stories * offers designated structural info together with cDNA and gene constitution for all proteins * Introduces supplement functionality, easily defined for every functionality * information is as up to date as attainable, together with unpublished paintings from many members * comprises area buildings diagrams, which superbly illustrate the connection among all of the supplement proteins, either inside, and among, households * every one bankruptcy has been written by way of a professional within the box * facts is as updated as attainable, together with unpublished paintings from many members Entries supply details on: * substitute nomenclature * Physiochemical homes * constitution and serve as * Tissue distribution and rules expression * Protein sequence/modules * Chromosomal situation * Genomic constitution * Database accession numbers * Deficiency and polymorphic editions * Key references
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SFTPD ... SFTPA2 ... Pseudogene ... SFTPAl ... Telomere^^ Gene names for SP-A are SFTPAl and 2 or SFTPl or PSAP and for SP-D are SFTPD, SFTP4 or PSPD. This region of the chromosome also contains the gene for MBL. Mouse: chromosome 14, 14 cM. cDNA sequence^^ CGGAGACCCA AGAAAGAGCA CTTGATGGCA TATCCCCGGC AGGAGACCCT AAATGATGGG TGGCGAGAGG CCACGACTTT AATGACGGTA TCAGGAGGCA TGAGGCCATT GGGTCCCAGC GTACCGAGGG GCAGTGGAAT ATTTAGGCCA CTTGGTCTGT AGCAGCTGGA GCGACTGGAC GCCTCTGGTG ACTCCTGGAT GGCCCTCCAG CTGCCTGGAG GGCCCTCCAG AGACATCAAA GGAGAGAAGG TGTGCCAGAG GCAAGCTTCG CCTGGAGACT GAGCCCGCAG GACAGGAACT TGGGACAGGG GAGATGCTAG GGCTCTGTGT CCAGAGCCAT CTGCGTGCGA CCCACGGCCT GCCCCATGGG CCCCTGGTAT GGCTTCCAGC TCCTGCAGAC TCTTCTCCAG CAGGCGGCCG TGAAGAAGTA TCCGCTACTC GTCGGGGAAA GCCTGTACTC AGGACGCTCT AACTCCCTTT GTGGGTCGCT GTGGCTGTGC AGTGAAGGAC GCCAGGCAGG TCCGCCTGGA CCCTGGAGAG TCATCTAGAT AAGGGGAGCC CAATGGGCAG CATTGCTGTC CAACACATAT AGACGGGACC AGAGCAGTGT CCGACTGACC CTGGCCTTCG CAACA GAGTTTCTTG CCTCTGGCCC GTTTGTGTTG GACGGGAGAG GAAATGCCAT TGTGGAGAGA GAGGAGCTCC CTCAGTCTGC TCCATCACTT CCAAGGAATC GCCTATGTAG CCTGTAAACT GTGGAGATGT ATCTGTGAGT GCCTCCATCC GAGCCTGAAA TCAACCTCAT GAAGCCCTGG ATGGTCTCAA GTCCTCCTGG AGGGGGAGCC AAGCCACACT AGGGCTCCAT TTGATGCCAT CAGAGGAAAA GCCTGACTGA ACACCAACTG ACACAGATGG TCTGAGAGGC TGAGGCTCCA 60 120 180 240 300 360 420 480 540 600 660 720 780 840 900 This is the sequence of an (x3 allele.
Et al. (1997) Lancet 349, 236-240. O. et aL (1995) J. ImmunoL 155, 3013-3020. O. et aL (1994) Immunogenetics 40, 37-44. M. Reid, Department of Biochemistry, University of Oxford, Oxford, UK Note: Conglutinin is believed to be restricted to bovidae. Despite extensive searching at the protein, cDNA and genomic levels, this gene product or gene appears not to be present in humans or mice. Physicochemical properties Bovine conglutinin is a 391 amino acid polypeptide chain including a 20 amino acid leader sequence.
M. (1998) In Human Protein Data (Haeberli, A. ) Wiley-VCH Verlag, Weinheim. 41 Nicole Thielens and Gerard J. Arlaud, Jean-Pierre Ebel Institute of Structural Biology, Grenoble, France Physicochemical properties Illlii •III ••li liiiiill liliill lllllli Human Clr is a non-covalent homodimer of M, (K) 173. Each monomer is synthesized as a single-chain proenzyme molecule of 705 amino acids including a 17 amino acid leader sequence. Activation occurs through cleavage of a single bond (R463-I464), yielding two disulfide-linked chains A and B.