By Simon J. Morley (auth.), Professor Dr. Robert E. Rhoads (eds.)
This quantity offers the reaction of the eukaryotic translational equipment to mobile pressure and apoptosis, together with kinases activated via either the ERK and stress-activated pathways. It extra explores brokers that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written through top specialists within the box supply either new information and entire literature experiences. either the rules of initiation and elongation are mentioned, and the mechanisms of apoptosis are regarding adjustments within the protein synthesis machinery.
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Extra info for Signaling Pathways for Translation: Stress, Calcium, and Rapamycin
Example text
Am J Physiol Endocrinol Metab 277:E805-E814 Laroia G, Cuesta R, Brewer G, Schneider RJ (1999) Control of mRNA decay by heat-shockubiquitin-proteosome pathway. Science 284:499-502 Lawrence JC Jr, Abraham RT (1997) PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci 22:345-349 Lazaris-Karatzas A, Montine KS, Sonenberg N (1990) Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345:544-547 Le H, Tanguay RL, Balasta ML, Wei CC, Browning KS, Metz AM, Goss DJ, Gallie DR (1997) Translation initiation factors eIF-is04G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity.
GCN2 is an eIF2a kinase that is activated upon amino acid starvation of yeast ceIls, leading to the specific expression of GCN4, a transcriptional activator of factors involved in amino acid synthesis. 1999; Sood et al. 2000). So far, the data suggest that this kinase is switched on only upon amino acid starvation, and a possible role in the stress-induced phosphorylation of eIF2a seems unlikely. PEK, or PERK (PKR-like endoplasmic reticulum kinase), has recently been identified as an endoplasmic reticulum resident eIF2a kinase that is specifically activated by ER stresses, such as treatment of cells with thapsigargin and tunicamycin.
M, Morley SJ (1998) Degradation of eukaryotic polypeptide chain initiation factor (elF) 4G in response to induction of apoptosis in human lymphoma celllines. Oncogene 17:2921-2931 Clemens MI, Bushel! M, Jeffrey IW, Pain VM, Morley SJ (2000) Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. Cell Death Differ (in press) Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16 Coldwel! M, Mitchel! SA, Stoneley M, MacFarlane M, Willis AE (2000) Initiation of Apaf-l translation by internal ribosome entry.