Renal Transport of Organic Substances by P. Deetjen (auth.), Doz. Dr. R. Greger, Doz. Dr. med. F.

By P. Deetjen (auth.), Doz. Dr. R. Greger, Doz. Dr. med. F. Lang, Prof. Dr. med. S. Silbernagl (eds.)

This publication is a suite of stories at the renal shipping of natural ingredients. the 1st chapters care for normal facets of the subject. the subsequent articles deal with the current wisdom at the renal trans­ port of particular compounds or sessions of natural ingredients, while the fmal bankruptcy on comparative body structure bargains with the renal trans­ port of natural components in non-mammalian vertebrates. The articles of this quantity have been awarded in an abbreviated shape as introductory lectures at a contemporary Symposium on Renal delivery of natural components. This convention used to be geared up by way of Prof. Deetjen and the editors, and used to be held in Innsbruck, Austria, in July 1980 on the division of body structure of the college of Innsbruck. in this convention the authors of the unfastened communications (published as abstracts unwell Renal body structure, 2 (3), pp 135-166 (1980) in addition to Drs. C. Gottschalk, T. Hoshi, K.C. Huang, J.P. Kokko, Ch. de Rouffignac, ok. Scharer, BM. Schmidt-Nielsen, and J.A. younger, who acted as chair­ individuals on the assembly, have been useful members to the discussions of the themes reviewed during this quantity. we are hoping that the booklet should be of worth to nephrologists, to renal physiologists, and to those that are keen on instructing body structure, pharmacology, and inner medicine.

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1n: Orloff J, Berliner RW (eds) Handbook of physiology, Sect 8. Am Physiol Soc, Washington, pp 399414 26. Schneider EG, Sacktor B (1980) Sodium gradient-dependent L-glutamate transport in renal brush border membrane vesicles. Effect of an intravesicular >extravesicular potassium gradient. J BioI Chern 255:7645-7649 27. Ullrich KJ, Rumrich G, Baldamus CA (1970) Mode of urea transport across the mammalian nephron. 1n: Schmidt-Nielsen B, Kerr DWS (eds) Urea and the kidney. Excerpta Medica, Amsterdam, pp 175-184 28.

6 mmol/l. The small secretory Ac vanished when Na+ or HC03 were omitted from the perfusates or when . , unpubl. J. Ullrich References 1. Baldamus CA, Radtke HW, Rumrich G, Sauer F, Ullrich KJ (1972) Reflection coefficient and permeability of urea in the proximal convolution of the rat kidney. J Membr BioI 7: 377-390 2. Berner W, Kinne R (1976) Transport of paraaminohippuric acid by plasma membrane vesicles isolated from rat kidney cortex. Pfliigers Arch 361 :269-277 3. Blomstedt JW, Aronson PS (1980) pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.

The magnitude of the changes depends on the type of substrate used and on its concentration. Usually a simple Michaelis-Menten type saturation kinetic is observed with substrate specific Km values and maximal potential changes. However, peritubular application of the same substrates does not yield comparable effects. 2 mY in response to 10 mmol/l of glutamine. These values are so small that it is difficult at present to determine whether they result from the operation of a transport system similar to that in the luminal cell membrane, which might be present in the peritubular cell membrane in much lower density, or whether they result from perfusion artifacts.

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