Progress in Nucleic Acid Research and Molecular Biology, by J.N. Davidson, Waldo E. Cohn (Eds.)

By J.N. Davidson, Waldo E. Cohn (Eds.)

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The first reaction is nil addition of BrOII to the 5,6double bond (Fig. 4). 5-dibromo-6-hydroxy-hydrocytosine. In alkali, 5-bromo-0-hydroxy-hydrocytosine may lose HBr, forming 5-hydroxycytosine. 4. Reaction of cytosiiie with 1)romirie-water at pH 7. It remains to be established whetJherthis is due to tautomeric shift or ionization resulting from reaction a, b, or d, or t o other causes. Studies concerning the mutational specificity of these reactions are in progress. An extensive literature exists on the incorporation of Fi-deoxybromouridine into DNA and of 5-fluorouracil into RNA (1-,5).

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Null. S. 60,657 (1963). 75. J. Ono, R. G. Wilson, and L. Grossman, J. Biol. 11, 600 (1965). M. Daniels and A. Grimison, Biochem. Biophys. Commun. 16, 428 (1964). 75. H. Schuster and H. G. Wittman, ViroZogy 19,421 (1963). R. M. Litman and H. Soi. 249, 838 (1959). 77. E. Cabrera-Juarez and R. M. Bacterial. 86,671 (1963). 78. A. Tsugita and H. Riot. 4, 73 (1962). 79. K. W. Brammer, Biochim. Biophys. Acta72, 217 (1963). 80. T. A. Trautner, M. N. Swartz, and A. Kornberg, Proc. Natl. Sci. 48,449 (1962).

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