Pregnancy Protein Research by Marie O'Leary

By Marie O'Leary

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2005) Pre-eclampsia (a review). Lancet, 365, 785799. D. M. (2002) Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J. Clin. , 87, 1762-1767. , Hughes, G. and Klopper, A. (1979) Studies on pregnancy-associated plasma protein A in the third trimester of pregnancy. Br. J. Obstet. , 86, 882887. , Zimmermann, W. S. (2001) Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes.

Hau, J. G. (1984) Placental protein measurements in complicated pregnancies. II. Pregnancy-related hypertension. Br. J. Obstet. , 91, 1224-1229. , (1982) Pregnancy-associated plasma protein A in normal and abnormal late pregnancy. T. Grudzinskas, B. Teisner, M. ), Pregnancy proteins (pp. 345 – 354). Sydney: Academic Press. , Lehavi, O. and Orr-Urtreger, A. (2002a) Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenat Diagn, 22, 778782. P. I. (1999) Second-trimester maternal serum marker screening: maternal serum alpha- 30 Lenka Fialová and Ivan Matouš-Malbohan fetoprotein, beta-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome.

The administration of melatonin decreases tyrosine hydroxilase activity and increases LH secretion; this modulation is independent of the action of the oestradiol. It is interesting to note that the inhibition of the enzyme tirosine hydroxilase activity, through a systemic injection of a dopamine antagonist (pimozide) during the anoestrous season, evokes a temporary increase in LH secretion. It is also known that PRL levels are high during anoestrous. In other species high PRL levels decrease upon administration of dopamine.

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