By Yann A. Henry Ph.D., Annie Guissani Ph.D., Béatrice Ducastel M.S. (auth.)
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Biochem Biophys Res Commun 1993; 193:1076-1082. 6. Lancaster JR. Simulation of the diffusion and reaction of endogenously produced nitric oxide. Proc Nat! Acad Sci USA 1994; 91:8137-8141. 7. Wood J, Garrhwaite J. Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties. N europharmacol 1994; 33:1235-1244. 8. Saran M, Bors W. Signalling by O2- and NO·: how far can either radical, or any specific reaction product, transmit a message under in vivo conditions?
122. Franchini A, Conte A, Ottaviani E. Nitric oxide: an ancestral immunocyte effector molecule. Adv Neuroimmunol 1995; 5:463478. 123. Sen S, Cheema IR. Nitric oxide synthase and calmodulin immunoreactivity in plant embryonic tissue. Biochem Arch 1995; 11:221-227. ~========~ CHAPTER 2~========~ BASIC CHEMISTRY OF NITRIC OXIDE AND RELATED NITROGEN OXIDES Yann A. Henry, Beatrice Ducastel and Annie Guissani T he general purpose of this chapter is to briefly recall the basic chemistry of NO·, especially its own paramagnetism and that of some of the complexes it forms with transition metals.
64 However the production could not be simultaneous; while NO biosynthesis requires several hours induction in the macrophages, the triggering of the respiratory burst induces immediate and transient release of reactive oxygen intermediates by NADPH oxidase (see below). 4), which should be written, contrarily to what is usually done, as between NO· + HO/. 1) x 10 7 mol·! 4 sec· 1) into the two strong oxidants, HO· and NO/, and nitrate. 7 6 All groups nearly agreed over the rates of peroxynitrite first order decay.