By Jaekwon Lee, David Adle, Heejeong Kim (auth.), Markus J. Tamas, Enrico Martinoia (eds.)
One of the demanding situations confronted through each cellphone in addition to through complete organisms is to keep up acceptable concentrations of crucial nutrient metals whereas except nonessential poisonous metals. towards that finish, all organisms have constructed mechanisms for steel homeostasis and detoxing to keep up steel degrees inside physiological limits. This ebook brings jointly present wisdom of the molecular foundation of steel homeostasis and cleansing in a number of eukaryotic version structures, together with yeasts, vegetation, and mammals. It makes a speciality of the mobile platforms controlling steel delivery, intracellular distribution, and immobilization in addition to on platforms regulating metal-dependent transcription. as well as environmental elements (including phytoremediation), the ebook treats the pathophysiology of steel deficiency and overload relating to disorder.
Read or Download Molecular Biology of Metal Homeostasis and Detoxification: From Microbes to Man PDF
Similar biology books
Transgenic Crops IV (Biotechnology in Agriculture and Forestry, Vol. 59)
Genetic engineering is a strong device for crop development. Crop biotechnology earlier than 2001 used to be reviewed in Transgenic plants I-III, yet fresh advances in plant telephone and molecular biology have brought on the necessity for brand new volumes. Transgenic plants IV offers with cereals, greens, root vegetation, herbs and spices.
- Nucleic Acids and Molecular Biology
- Membrane Processes: Molecular Biology and Medical Applications
- G Protein Signaling: Methods and Protocols (Methods in Molecular Biology Vol 237)
- Avian Influenza Virus
- Methods in cell biology / Vol. 46, Cell death / edited by Lawrence M. Schwartz and Barbara A. Osborne
Extra resources for Molecular Biology of Metal Homeostasis and Detoxification: From Microbes to Man
Sample text
2000). 5 Regulation of Cu metabolism by stress and other nutritional factors The Cu transport machinery is not only regulated by extracellular Cu levels but also by growth conditions such as pH and nutrient limitations. First, many other genes relevant to Cu and Fe metabolism such as Fre1, Ctr1, Lys7, and Ccc2 are induced when cultured in an alkaline media (Serrano et al. 2002, 2004). Consistently, yeast cells with deletions in any of these genes are sensitive to alkaline pH, and overexpression of the Ctr1 or Fet4 Cu transporters confers resistance to alkaline pH (Serrano et al.
Cerevisiae in addition to Ccc2 has been designated as Pca1 (putative P-type cation-transporting ATPase) (Rad et al. 1994). Pca1’s role in Cu homeostasis remains obscure. Pca1 is a large 132kD transmembrane protein consisting of 1216 amino acid residues. Pca1 has one N-terminal MTCXXC metal binding motif compared to the two found in Ccc2. Mammals possess two P-type ATPases, which are WND and MNK, and another yeast species C. albicans expresses two P-type ATPases that play independent roles, Cu incorporation at the secretory pathway and Cu export to reduce intracellular Cu accumulation.
Cox23 unlike Δcox19 mutants can be rescued by exogenous Cu, however, only when transformed with a Cox17 high copy plasmid. Conversely, overexpression of Cox23 does not suppress the Δcox17 respiratory deficient phenotype suggesting that Cox17 functions downstream of Cox23 in the same pathway possibly involving Cox19 (Barros et al. 2004). One thing that is apparent now is that Cu homeostasis in the mitochondria is much more complicated than once previously thought. Recently, the role of Cox17 as the main mitochondrial Cu shuttle has come into doubt.