By Richard Champlin, Sergio Giralt, James Gajewski (auth.), Nader G. Abraham, Shigetaka Asano, Günther Brittinger, Georges J. M. Maestroni, Richard K. Shadduck (eds.)
This quantity of Molecular Biology of Hematopoiesis is devoted to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for his or her contributions in constructing an total view of the state of the art wisdom within the box of hematopoiesis. Richard Champlin, between different popular clinicians, provided up to date info on stem cells and T-cell depletion for bone marrow transplant. A scientific replace on thrombopoietin used to be offered by way of Pamela Hunt of Amgen and via Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our present wisdom and advances within the fields of development elements and gene move have been additionally famous in the course of the ninth Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters disguise such varied components as preclinical and medical updates on progress elements and optimistic and detrimental regulatory molecules. "Advances in Leukemia: Mechanism and therapy through Interferon" used to be offered via Professor Sante Tura. Readers will locate presentation of interesting advances that experience happened within the quarter of hematopoiesis. The elucidation of gene buildings of key development issue proteins corresponding to IL-12 and IL-II will result in new insights and new ways in knowing the law of hematopoiesis, in addition to program of recent development factors.
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Extra info for Molecular Biology of Hematopoiesis 5
Example text
Forty-eight patients were included and 30 have currently been grafted. Characteristics of these 2 groups of patients are indicated in Table 1. Median age of tlie patients was 55 years with 12 patients aged more than 60 years. Twenty-four patients had AML while 24 had various lymphoid malignancies. Thirty patients were in complete or partial response after their first line therapy while 18 had advanced disease, 2 of them having relapsed after previous bone marrow transplantation. Mobilization, Harvest and Cryopreservation of Peripheral Blood Stem Cells Patients were treated with G-CSF (filgrastim), 5 ~g/kg/day, SC, initiated while blood counts were within normal limits after hematopoietic recovery of previous course of Table 1.
05) compared to pretreatment value. 05) compared to G-CSF treated patients. BM specimens were analyzed for the content of CD 34+ cells (Table 1). However, neither group of patients showed the increase of more immature, myeloid lineage negative CD 34+ CD 33- cells. 6 ± 3% to 35± 6%, respectively, in patients administered CSF combination (Table 2). 05 compared to baseline value) but not of BFU-E. However, this increase was significantly lower than that observed in the posttreatment samples of patients receiving IL-3 in addition to G-CSF (Table 2).
Immature CD4+CD8+ double positive (DP) T-cells are low in Class I HLA expression, and acquire a higher Class I HLA expression at final stages of maturation ( reviewed in (6)). Cells being processed through the thymic fragment in the SCID-hu BTS grafts should therefor have variable fluorescence intensities when stained with a donor Class I HLA MAb. Histogram analysis of single positive CD4+and CD8+ cells for donor Class I HLA expression demonstrates that mature T-cells in the SCID-hu BTS grafts express high levels of donor Class I HLA, immature DP T-cells however, express low to negative levels (Figure 2 and data not shown).