By Janine Cossy, Stellios Arseniyadis, Christophe Meyer, Robert H. Grubbs
Emphasizing the effect of metathesis in common product synthesis during the kinds of key reactions, it is a accomplished view of a sizzling subject. Written via most sensible foreign authors, this prepared reference is obviously established and filled with very important info, together with consultant experimental techniques for useful applications.A actual must-have for somebody operating in ordinary product synthesis.
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Extra info for Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts
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Trauner et al. 11) [14]. The cyclization precursor was prepared via an asymmetric ene reaction of glyoxylate 72. Further transformations led to 1,6-diene 74 that could be cyclized to cyclopentenone 75 in 86% yield using [Ru]-II (5 mol%). Conjugate addition of the organocuprate 76 then established the C11 quaternary stereocenter. The central seven-membered ring was then closed with an electrochemical oxidation. ) Karst. 2 Formation of Five-membered Carbocycles by RCM O R*O Steps R*O SnCl4, −78 °C O [Ru]-II (5 mol%) OH O 72 O 73 (dr = 10 : 1) R = (1S,2R )-2-Phenylcyclohexyl OBn Toluene, reflux 86% OBn O 74 75 Cu(CN)(2-Th)Li2 PO O 76: P = TBDPS 1.
Int. , 47, 6201–6203. Tiefenbacher, K. and Mulzer, J. (2008) Angew. Chem. Int. , 47, 6199–6200. J. (2008) Angew. Chem. Int. J. (2008) Angew. Chem. Int. , 47, 1780–1783; (c) Hayashida, J. H. (2008) Angew. Chem. Int. , 47, 4373–4376. , and Ihara, M. (2001) J. Am. Chem. , 123, 1856–1861. Ciochina, R. B. (2006) Chem. , 106, 3963–3986.
When possible, comparison between various catalysts and experimental conditions is also discussed. Challenging RCM was reported during the synthesis of the ABE tricyclic analogs 259 of the alkaloid methyllicaconitine (256), a competitive antagonist of nicotine acetylcholine receptors [63]. The B ring system was synthesized via a [Ru]-I catalyzed RCM of the 1,8-diene 257 possessing two contiguous quaternary stereogenic centers. 47). A key step in the total synthesis of (±)-frondosin B (260) reported by Mehta and Likhite is RCM of 1,8-diene 262 using [Ru]-I (C6 H6 , reflux) [64].