Low-Grade Gliomas by Stephen J. Price (auth.), J. Schramm (eds.)

By Stephen J. Price (auth.), J. Schramm (eds.)

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Pleomorphic xantoastrocytoma (WHO grade II) . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Pilocytic astrocytoma (WHO grade I) . . . . . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Subependymal giant cell astrocytoma (WHO grade I) . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics .

Oligodendroglioma (WHO grade II). . . . . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Oligoastrocytoma (WHO grade II) . . . . . . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics . . . . . . . . . . . . . . . . Ependymoma (WHO grade II) . . . . . . . . . . . . . Epidemiological, histological and immunohistochemical features Molecular genetics .

51 51 51 51 51 52 53 53 56 57 Abstract The term ‘‘low-grade glioma’’ refers to a heterogeneous group of slowly growing glial tumors corresponding histologically to World Health Organization (WHO) grade I or II. This group includes astrocytic, oligodendroglial, oligoastrocytic and ependymal tumor entities, most of which preferentially manifest in children and young adults. Depending on histological type and WHO grade, growth patterns of low-grade gliomas are quite variable, with some tumors diffusely infiltrating the surrounding central nervous system tissue and others showing well demarcated growth.

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