By H. Schaller (auth.), Th. Bücher, H. Sies (eds.)
The scope of the 20 th Mosbach Colloquium could be top illustrated via the next notes despatched to the audio system whilst the colloquium was once prepared. "1) the applying of inhibitors in cellphone biology has ended in decisive perception into the agency of mobile devices. the topic might be handled opposed to a history of present elements of phone biology. In a few parts of study, a pretty entire photograph of the features and cooperative interactions of the devices has already emerged. we'll speak about usually those parts. 2) At this colloquium we wish to give a contribution illustrations of the priceless software of inhibitors to organic difficulties. because of restricted wisdom, inhibitors are often incorrectly hired. this is applicable either to the making plans of investigations and to the con· clusions drawn ("use of inhibitors by means of uninhibited workers"). three) Inhibitors themselves are fascinating elements and their mechanisms of motion represent attention-grabbing problems." The colloquium has been subdivided into 5 sections. The recognized chemical buildings of the inhibitors mentioned are given in an Appendix. We gratefully have fun with the cooperation of the audio system. To an outstanding volume, they controlled the coordination of contributions to every of the 5 subdivisions. We remorse that no individuals from japanese Europe have been in a position to participate.
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The inhibitory effect of granaticin on growth and nucleic acid synthesis can also be reversed by cystein, not by reducing agents. A second possibility to explain the inhibitory effect of quinones on nucleic acid synthesis is that the quinones interfere with the phosphorylation of the precursors. g/ml Granatlcln 0 01 02 03 % cpm/OD 4/55 165 235 1548 1423 948 102 1607 1278 891 92 1569 1280 875 87 Inhibition 10-20 40-45 90-95 Fig. 14. The effect of granaticin on the synthesis of sRNA, 16 S rRNA and 23 S rRNA in B.
Molec. BioI. 14, 179 (1965). 46. , and R. HAYES: Biochem. biophys. Res. Commun. 19, 462 (1965). 47. , and P. ) 206,480 (1965). 48. , and W. CARRIER: J. molec. BioI. 1'1, 237 (1966). 49. , and P. HOWARD-FLANDERS: Proc. nat. Acad. Sci. ) iiI, 293 (1964). 50. KOHN, K. , N. H. STEIGBIGEL, and C. L. SPEARS: Proc. nat. Acad. Sci. ) li3, 1154 (1965). 51. STRAUSS, B. , and M. RUBBINS: Biochim. biophys. ) 161, 68 (1968). 52. , and C. L. DAVISON: Biochem. biophys. Res. Commun. 1'1, 608 (1964). 53. : Z. physiol.
Other compounds exert their influence as inactivators of the template which directs the course of RNA synthesis. Finally, some inhibitors act as specific poisons of the catalytic activity of the enzymic protein itself. Since bivalent metal ions are required for the reaction, chelating agents also block RNA biosynthesis. In vivo, however, chelating agents cannot be used as specific inhibitors, since many cellular reactions are metal ion dependent and would be blocked simultan~ously. 1. Substrate Analogues A well known example of antimetabolites suppressing the RNA polymerase reaction is cordycepin triphosphate [5].