By Heinz Köhler, Jacques Urbain, Pierre-André Cazenave, Heinz Kohler
Idiotypy in Biology and drugs goals to serve the expanding curiosity and involvement within the functional features of idiotypy in organic platforms. the concept that of idiotypy has got huge popularity and curiosity some distance past the realm of immunology. Experiments and interpretation of findings, pronounced right here, essentially help the overall nature of the idiotype idea in manipulating organic structures to right pathological stipulations or to enhance the immune version to environmental elements.
The ebook is geared up into 3 sections. part 1 discusses unique suggestions of idiotypic manipulations. It experiences previous and up to date information vital for the idea that of an idiotype community and stories on makes an attempt to accommodate the T-cell receptor paradox; explains the immune process by way of a round idiotype community that may be verified by means of sequential immunization; and emphasizes the necessity for regulations in community interactions. part 2 addresses the function and task of idiotypic and antiidiotypic antibodies within the legislation of the immune process. part three takes the problem of idiotype-antiidiotype out of the world of the immune method and discusses it as a brand new precept to investigate and manage organic platforms often.
Read Online or Download Idiotypy in Biology and Medicine PDF
Best biology books
Transgenic Crops IV (Biotechnology in Agriculture and Forestry, Vol. 59)
Genetic engineering is a robust device for crop development. Crop biotechnology earlier than 2001 used to be reviewed in Transgenic vegetation I-III, yet fresh advances in plant phone and molecular biology have triggered the necessity for brand new volumes. Transgenic plants IV offers with cereals, greens, root plants, herbs and spices.
- Transmembrane Signaling Protocols
- Kurzlehrbuch Biologie (German Edition)
- Oxidants and Antioxidants: Ultrastructure and Molecular Biology Protocols, 2002nd Edition
- Electron Microscopy: Methods and Protocols
- Biological Microarrays: Methods and Protocols
- The Molecular Biology of Physarum polycephalum
Additional resources for Idiotypy in Biology and Medicine
Sample text
Pp. 437-447. 7. , and Paul, W. E. /. Exp. Med. 153, 951. 8. -A. (1977). Proc. Natl. Acad. Sci. A. 74, 5122. 9. , and Caulfield, M. J. /. Immunol. 126, 2262. 10. , Julius, M. , and Augustin, A. A. (1977). Immunol. Rev. 34, 3. 11. Dzierzak, E. , and Janeway, C. A. /. Exp. Med. 154, 1442. 12. , and Kohler, H. /. Exp. Med. 156, 539. 13. Grey, H. , and Kunkel, H. G. /. Exp. Med. 121, 561. 14. , and Baker, P. J. /. Exp. Med. 153, 1004. 15. , and Bona, C. (1982). Proc. Natl. Acad. Sci. A. 79, 1616.
1 5 2 , 1024-1035. 35. Zinkernagel, R. , and Doherty, P. (1977). Contemp. Top. Immunobiol. 7, 1 7 9 214. Chapter 3 Regulatory Idiotopes Constantin A . Bona Department of Microbiology Mount Sinai School of Medicine New York, New York I. Introduction II. Immunochemical Properties of Syngeneic A b 1 , Ab2, Ab3, and Ab4 III. Functional Properties of Syngeneic Ab1, Ab2, Ab3, and Ab4 Antibodies A. Effect on the Antibacterial Levan Response B. Antitumor Properties of Ab2, Ab3, and Ab4 IV. Regulatory Idiotype Network References 29 30 33 34 36 36 41 I.
Combining sites) and each capable o f being recognized by the other clones because they express idiotopes on their antigen binding receptors. A key factor in this concept is the potential importance of receptor-specific regulation o f the immune system in contrast to antigen-specific regulation, as postulated by clonal theory. Network theory predicts a vectorial character in these paratope-idiotype interactions. Indeed, it was predicted that A b l bearing a paratope (designated p i ) and an idiotope (termed i l ) can elicit the production o f Ab2 which expresses p2 (specific for i l ) and an idiotope (i2).