By Errol Zeiger (auth.), Alok Dhawan, Mahima Bajpayee (eds.)
Genetic toxicology is famous through geneticists and researchers occupied with the genetic effect of artificial chemical compounds. In Genotoxicity review: equipment and Protocols, specialist researchers within the box supply finished genetic toxicology protocols. those comprise in vitro and in vivo protocols on mutation assays, cytogenetic options, and first DNA harm, assays in trade to animal versions, and up-to-date ICH instructions. Written within the hugely winning Methods in Molecular Biology sequence structure, the chapters contain introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step and with ease reproducible laboratory protocols, in addition to key pointers on troubleshooting and fending off recognized pitfalls.
Authoritative and state of the art, Genotoxicity overview: equipment and Protocols seeks to assist learn scholars and scientists operating in regulatory toxicology in addition to biomedical, biochemical and pharmaceutical sciences.
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Extra info for Genotoxicity Assessment: Methods and Protocols
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Mutat Res 291:171–180 Kushida H, Fujita K, Suzuki A et al (2000) Development of a Salmonella tester strain sensitive to promutagenic N–nitrosamines: expression of recombinant CYP2A6 and human NADPH–cytochrome P450 reductase in S. typhimurium YG7108. Mutat Res 471: 135–143 25 48. Fujita K, Nakayama K, Yamazaki Y et al (2001) Construction of Salmonella typhimurium YG7108 strains, each co–expressing a form of human cytochrome P450 with NADPH–cytochrome P450 reductase. Environ Mol Mutagen 38:329–38 49.
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