Cryptococcus : from human pathogen to model yeast by Joseph Heitman; et al

By Joseph Heitman; et al

That includes greater than a hundred professional authors from worldwide, this e-book bargains the entire diversity of clinical and scientific views had to create this distinct, accomplished evaluate of Cryptococcus. It covers either the Cryptococcus neoformans and Cryptococcus gattii species, studying intimately the lifestyles cycle, pathophysiology, molecular biology, genetics, genomics, epidemiology, immunology, and clinical Read more...

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Med. Mycol. 45:469–473. 19. Buschke, A. 1895. Über eine durch coccidien hervorgerufene Krankheit des Menschen. Dtsch. Med. Wochenschr. 21:14. 20. Busse, O. 1894. Über parasitäre Zelleinschlüsse und ihre Züchtung. Zentralbl. Bakteriol. 16:175–180. 21. Busse, O. 1895. Über Saccharomycosis hominis. Virchows Arch. A. 140:23–46. 22. , I. Spencer-Martins, and N. Gunde-Cimerman. 2007. Yeasts in high Arctic glaciers: the discovery of a new habitat for eukaryotic microorganisms. Antonie Van Leeuwenhoek 91:277–289.

G. Mitchell. 2006. Multilocus sequence typing reveals three genetic subpopulations of Cryptococcus neoformans var. grubii (serotype A), including a unique population in Botswana. Genetics 172:2223–2238. 82. , and N. J. W. Kreger-Van Rij. 1952. The Yeasts: a Taxonomic Study. North Holland, Amsterdam, The Netherlands. 83. , B. S. Orozco, and E. Mylonakis. 2006. The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions. FEMS Yeast Res. 6:567–573.

This technical advancement allowed the routine use of the transformation system to efficiently produce site-specific gene knockouts or mutants, and now the field has exploded with the creation of site-specific mutants for impact on pathogenesis. Over 150 knockout mutants have been studied for pathogenesis impact on disease in a variety of animal models (72). These models of disease range from the use of mammals such as mice, rats, and rabbits (43, 74) to invertebrates such as worms and grubs (46, 64).

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