A well timed quantity facing the evolutionary and structural hyperlinks among the clotting and fibrinolytic proteins and plasminogen-related progress elements. The function of person domain names for enzymatic proteins and plasminogen-related progress components is additionally comprehensively tested.
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The goal of this study was to see if Ron and HGFl/MSP are linked in this organism. It is too early to tell whether they are linked, but we have identified genomic clones. All we have to d o is get back to the UK MRC Human Genome Mapping Project Resource Centre here in England and get those clones. Gberardi: Did you isolate clones for HGPjSF and Met at the same time? FrieTner Depnn:W e don’t know yet whether we did o r not. We used mouse c D N A sequences t o probe the puffer fish library. It is too early to say for sure that these clones actually code for Ron and HGFI/MSP: they could be homologues.
Stern: Certainly, in development their patterns of expression are quite different. Sea doesn’t seem to be expressed early, whereas Ron in mammals is (C. Thery & C. D. Stern, unpublished results). Gherardi: This raises a point mentioned earlier: d o we know all the members in the family o r only some of them? Is Sea hinting at the presence of at least a third receptor type? Comoglio: I can give you some experimental data. First, HGFl/MSP does not bind to Sea. Second, we have been looking for the counterpart of Sea in a number of different living organisms for about five years now.
Gberardi: In evolutionary terms, it may reflect a duplication event of a locus that had both ligand and receptor. The evolutionary argument would be that if you have a locus which encodes both ligand and receptor, and that is duplicated, then you generate a pair of ligands and a pair of receptors. If you let these diverge then you may end up with biological activities as diverse as those of HGFl/MSP and HGF/SF. H o w this relates to pathology is not clear. Crumpton: I don’t think that the location of genes in chromosomes is largely influenced by their function o r their relationship.