By Colm McDonald, Katja Schulze, Robin Murray, Padraig Wright
This publication makes a speciality of the hot surge in study into the pathogenesis and remedy of bipolar affliction, and severely analyses the facts aiding some of the traditional reviews in regards to the sickness. Chapters via best uncomplicated technology and medical researchers from North the US and Europe deal with concerns together with the very nature of the illness (psychological illness or mind disease), the function of genetics, the position of cortisol, and the consequences of long term therapy. in accordance with lectures offered as a part of the second one ecu origin for Psychiatry on the Maudsley (EFPM) assembly, this ebook will stimulate dialogue and debate on novel perspectives and may query the dogmas of current perform.
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Extra resources for Bipolar Disorder: The Upswing in Research and Treatment (European Foundation for Psychiatry at the Maudsley)
E Serap Monkul and Jair C Soares This chapter focuses on recent work that has utilized in vivo brain imaging to understand the mechanisms involved in bipolar disorder. 2,3 One of the regions of interest is the anterior cingulate, which is thought to be involved in the pathophysiology of mood disorders. 4 Reduction in anterior cingulate grey matter volumes4,5 and density6,7 is a consistently reported finding in recent studies. 8 Ch 03 7/4/05 22 3:36 pm Page 22 Bipolar disorder: the upswing in research & treatment Another region that has attracted much attention for research on the pathophysiology of mood disorders is the amygdala, which is involved in regulation of emotions such as fear and anxiety.
Dazzan P, Morgan K, Orr KG et al, Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study. Neuropsychopharmacology in press. Moore GJ, Bebchuk JM, Wilds IB et al, Lithium-induced increase in human brain grey matter. Lancet 2000; 356:1241–1242. Sassi RB, Nicoletti M, Brambilla P et al, Increased gray matter volume in lithium-treated bipolar disorder patients. Neurosci Lett 2002; 329:243–245. McDonald C, Bullmore E, Sham P et al, Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: a computational morphometry study.
7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 35 Videbech P, MRI findings in patients with affective disorder: a meta-analysis. Acta Psychiatr Scand 1997; 96:157–168. Dunn G, Design and Analysis of Reliability Studies: The Statistical Evaluation of Measurement Errors. Edward Arnold: London, 1989. Higgins JP, Thompson SG, Deeks JJ, Altman DG, Measuring inconsistency in meta-analyses. BMJ 2003; 327:557–560. Egger M, Davey Smith G, Schneider M, Minder C, Bias in meta-analysis detected by a simple, graphical test.