By W.E. Hennink, J.A. Cadée, S.J. de Jong, O. Franssen, R.J.H. Stenekes, H. Talsma (auth.), Emo Chiellini, Junzo Sunamoto, Claudio Migliaresi, Raphael M. Ottenbrite, Daniel Cohn (eds.)
Proceedings of the 3rd overseas Symposium on Frontiers in Biomedical Polymers together with Polymer Therapeutics: From Laboratory to medical perform, held could 23-27, 1999, in Shiga, Japan.
This e-book specializes in the growth and detailed discoveries within the interdisciplinary medical and technological zone of biomedical software of polymers. the subjects contain polymeric fabrics for biomedical and pharmaceutical purposes, in addition to polymeric fabrics in therapeutics.
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Additional resources for Biomedical Polymers and Polymer Therapeutics
Nanospheres could act by facilitating the cellular uptake of DNA and protecting it from degradation due to nucleases and lysosomal enzymes. Leong’s group has used cationic chitosan to formulate nanoparticles for gene transfer. A recent study from this group has demonstrated protection of animals against peanut allergy following oral administration of chitosan nanoparticles containing the gene for peanut allergen. Furthermore, they have higher secretory IgA antibody levels with chitosan-DNA nanoparticles as compared to a direct 25 injection of naked DNA .
1 Characteristics of the immunoliposome Figure 7 shows the structure of MCC-465, which is the immunoliposome encapsulated adriamycin. The liposome is tagged with PEG and a monoclonal antibody. The antibody bound to liposome is humanized F(ab’) 2. At the present time, the epitope to be recognized by the antibody has not been well characterized, probably because the antibody recognizes the conformation of an epitope. Up to now, it has been found that the epitope is on the cell surface and 90% of gastric cancer tissue is positively stained while normal cells are always negative (data not shown).
P. A. Hubbell, 1993, Macromolecules. 26: 581-587. 48. E. Y. J. E. Hennink, 1997, Polymer. 38: 6235-6242. J. E. J. W. E. Hennink, 1998, Macromolecules. 31: 6397-6402. A. Cadée, M. J. de Groot, W. E. Hennink, 1999, Polymer, in press. L. S. P. , 1991, J. Pharm. Sci. 80: 778-782. O. E. Hennink, 1998, Int. J. Pharm. 168: 1-7. H. Stenekes, O. G. A. E. Hennink, 1998, Pharm. Res. 15:555-559. H. E. Hennink, 1999, Int. J. Pharm. 168: in press. O. H. E. Hennink, 1999, J. Controlled Release. 59: 219228. O.