Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Background Lesions in Laboratory Animals can be a useful relief to pathologists desiring to acknowledge heritage and incidental lesions whereas interpreting slides taken from laboratory animals in acute and persistent toxicity experiences, or whereas interpreting unique species in a diagnostic laboratory. It provides transparent descriptions and illustrations of the vast majority of historical past lesions prone to be encountered. a number of the lesions lined are strange and will be fallacious for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all of the laboratory animal species coated and who've released widely in those areas.

  • over six hundred high-definition, most advantageous colour pictures of historical past lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive structures of all laboratory animals written through Dr Dianne Creasy, an international specialist on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts that could be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, really in rats in mice that are used for carcinogenicity studies

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Additional resources for Background Lesions in Laboratory Animals. A Color Atlas

Example text

97 Focal hyperplasia of the pars distalis of the rat pituitary. ×100. 95 Rathke’s pouch remnants in the rat pituitary gland. ×100. 98 Hyperplasia of pars distalis in rat pituitary with an unremarkable vascular pattern. ×200. e. the dilatation of bloodfilled spaces in the adenohypophysis (Fig. 96) of the pituitary, is common in older rats (Frith et al 2000a). 100 Cortical vacuolation in the rat adrenal gland. ×200. 101 Cortical cystic degeneration in the rat adrenal gland. ×200. 102 Cortical hyperplasia and vacuolation in the rat adrenal gland.

76 Hepatocyte lipofuscin pigment present in rat liver. ×400. 28 BACKGROUND LESIONS IN LABORATORY ANIMALS hydronephrosis or pelvic dilatation is seen commonly in rat kidneys. It is often unilateral and the right kidney is more commonly affected than the left (Hard et al 1999) (Fig. 80). commonly in aging rats is likely to be lipofuscin (Schmorl’s-positive) (Fig. 82). Cystic tubules can manifest in different forms and are generally found in the cortex. They can be single or multiple and are generally lined with a single layer of flattened epithelium (Hard et al 1999).

Liver and biliary system. ), Jubb, Kennedy & Palmer’s pathology of domestic animals, vol. 2. fifth ed. Saunders, Edinburgh, p. 312. , 1990. Spleen, lymph nodes and thymus. , et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 369–393. , 1984. Spontaneous eye lesions in laboratory animals: incidence in relation to age. Crit. Rev. Toxicol. 12, 121–147. , 2010. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicol. Pathol. 38, 5S–81S. , 1993.

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