By Heinz A. Staab, H. Bauer, K. M. Schneider
Within the overdue fifties and early sixties H. A. Staab chanced on N,N'-carbonyl-diimidazole (CDI), its analogues, and the family members of azolides derived from them. quickly those compounds turned commonly liked as man made development blocks of unsurpassed range. The spectrum of drugs, that may be bought through light acylation with azolides comprises esters, amides, ketones, aldehydes, in addition to heterocycles, peptides, glycosides, and nucleotides.
Now, H. A. Staab, the 'father' of those necessary compounds, with his coauthors H. Bauer and ok. M. Schneider, has accrued their guidance, homes, and manifold purposes in a entire and topical overview.
Are you within the box of synthesis of common items, biomolecules, heterocycles, or different complex natural compounds? Then, your first look could good be into 'Staab'- this guide must always be within sight of your table or lab bench.
Read Online or Download Azolides in Organic Synthesis and Biochemistry PDF
Best organic books
Catalyzed Carbon-Heteroatom Bond Formation
Written through an skilled editor greatly acclaimed in the clinical neighborhood, this e-book covers every thing from oxygen to nitrogen functionalities. From the contents: Palladium-Catalyzed Syntheses of 5-membered Saturated Heterocycles The Formation of Carbon-Sulfur and Carbon-Selenium Bonds by way of Substitution and Addition Reactions Catalyzed by way of Transition steel Complexes Palladium-Catalysis for Oxidative 1,2-Difunctionalization of Alkenes Palladium-Catalyzed Formation of fragrant Heterocycles Rhodium-Catalyzed Amination of C-H-Bonds Transition Metal-Catalyzed Synthesis of Heterocycles Copper-Catalyzed Synthesis of Azoles Palladium(II)-Catalyzed C-N Bond Formation regarding Aminopalladation of Aklenes Carbon-Heteroatom Bond Formation by means of Rh(I)-Catalyzed Ring-Opening Reactions contemporary Advances in Homogeneous Gold Catalysis: Formation of Carbon-Heteroatom Bonds the result's an integral resource of data for the strategic making plans of the substitute routes for natural, catalytic and medicinal chemists, in addition to chemists in undefined.
The 1st name during this zone in lots of years, this name brings jointly the entire parts of curiosity in natural reactions concerning carbocations in a single convenient quantity. It covers new components corresponding to nuclear decay new release, artificial purposes and NMR observations. additionally incorporated is wide and exact insurance of theoretical and gasoline section info.
Advances in Heterocyclic Chemistry
Content material: Microwave irradiation for accelerating natural reactions. half I: Three-, 4- and 5-membered heterocycles / E S H El Ashry, E Ramadan, AA Kassem, M Hagar -- Organometallic complexes of the n²(N, C)-coordinated derivatives of pyridine / Alexander Sadimenko -- Annulated heterocyclo-purines II: fused six- and more-membered heterocyclo-purinediones, -purinones and -purineimines / Alfonz Rybar -- Flourine-containing heterocycles.
Chromium Oxidations in Organic Chemistry
Chromium oxidation, popular and generally explored in natural chemistry because the very starting of this technology, is a subject of present curiosity for the natural chemist as evidenced via the continual improvement of latest techni ques and systems pronounced within the literature. Chromium oxidation is an easy approach which are simply played within the laboratory and scaled up in to boot.
- Steroid Chemistry at a Glance
- Application of Transition Metal Catalysts in Organic Synthesis
- Activating Unreactive Substrates The Role of Secondary Interactions
- Advances in Heterocyclic Chemistry, Vol. 56
Additional info for Azolides in Organic Synthesis and Biochemistry
Sample text
1 Syntheses ofCarboxylic Esters 29 alcohol component, have been synthesized in excellent yields by the imidazolide method with reaction times of only a few minutes at room temperature. [15]>[16] Working with Nprotected L-W-methylvaline and GDI, esterification of the hydroxyl group on the threonine residue proved successful whereas this could not be accomplished by any of the conventional methods. -nitrophenol at room temperature; however, better yields of these esters could be achieved by use of JV-trifluoroacetylimidazole.
Schaller, H. A. Staab, Chem. Her. 1961, 94, 1612-1621. [25] F. Cramer, H. Schaller, Chem. Ber. 1961, 94, 1634-1640. [26] W. Walter, M. Radke, Liebigs Ann. Chem. 1979, 1756-1767. [27] S. Berner, K. Muehlegger, H. Seliger, Nudeosides Nudeotides 1988, 7, 763-767; S. Berner, K. Muehlegger, H. Seliger, Nudeic Adds Res. 1989, 17, 853-S64. [28] T. M. Cao, S. E. Bingham, M. T. Sung, Tetrahedron Lett. 1983, 24, 1019^1020. [29] H. Ozaki, S. Yamoto, S. Maikuma, K. Honda, T. Shimidzu, Bull. Chem. Soc. Jpn.
Chem. 1959, 74, 164 (H. A. Staab, GDCh-Lecture Dec. 18, 1958). [8] G. W. Anderson, R. Paul, J. Amer. Chem. Soc. ); R. Paul, G. W. Anderson, ibid. 1960, 82, 4596-4600. [9] H. A. Staab, G. Maleck, Chem. Ber. 1966, 99, 2955-2961. [10] H. A. Staab, G. Walther, Liebigs Ann. Chem. 1962, 657, 98-103. [11] H. A. Staab, G. Walther, Chem. Ber. 1962, 95, 2070-2072. [12] H. A. Staab, M. Liiking, F. H. Durr, Chem. Ber. 1962, 95, 1275-1284. [13] H. A. Staab, D. Lauer, Chem. Ber. 1968, 101, 864-878. [14] H. A.