Azolides in Organic Synthesis and Biochemistry by Heinz A. Staab, H. Bauer, K. M. Schneider

By Heinz A. Staab, H. Bauer, K. M. Schneider

Within the overdue fifties and early sixties H. A. Staab chanced on N,N'-carbonyl-diimidazole (CDI), its analogues, and the family members of azolides derived from them. quickly those compounds turned commonly liked as man made development blocks of unsurpassed range. The spectrum of drugs, that may be bought through light acylation with azolides comprises esters, amides, ketones, aldehydes, in addition to heterocycles, peptides, glycosides, and nucleotides.

Now, H. A. Staab, the 'father' of those necessary compounds, with his coauthors H. Bauer and ok. M. Schneider, has accrued their guidance, homes, and manifold purposes in a entire and topical overview.

Are you within the box of synthesis of common items, biomolecules, heterocycles, or different complex natural compounds? Then, your first look could good be into 'Staab'- this guide must always be within sight of your table or lab bench.

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1 Syntheses ofCarboxylic Esters 29 alcohol component, have been synthesized in excellent yields by the imidazolide method with reaction times of only a few minutes at room temperature. [15]>[16] Working with Nprotected L-W-methylvaline and GDI, esterification of the hydroxyl group on the threonine residue proved successful whereas this could not be accomplished by any of the conventional methods. -nitrophenol at room temperature; however, better yields of these esters could be achieved by use of JV-trifluoroacetylimidazole.

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Chem. 1959, 74, 164 (H. A. Staab, GDCh-Lecture Dec. 18, 1958). [8] G. W. Anderson, R. Paul, J. Amer. Chem. Soc. ); R. Paul, G. W. Anderson, ibid. 1960, 82, 4596-4600. [9] H. A. Staab, G. Maleck, Chem. Ber. 1966, 99, 2955-2961. [10] H. A. Staab, G. Walther, Liebigs Ann. Chem. 1962, 657, 98-103. [11] H. A. Staab, G. Walther, Chem. Ber. 1962, 95, 2070-2072. [12] H. A. Staab, M. Liiking, F. H. Durr, Chem. Ber. 1962, 95, 1275-1284. [13] H. A. Staab, D. Lauer, Chem. Ber. 1968, 101, 864-878. [14] H. A.

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